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KMID : 1123920110250010084
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Korean Journal of Oriental Physiology and Pathology
2011 Volume.25 No. 1 p.84 ~ p.91
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Effects of Gyeonbi-Tang Treatment on the Monosodium Iodoacetate-induced Mild Osteoarthritis in Rats
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Park Dong-Su
Kim Soon-Joong
Jeong Su-Hyeon
Seo Il-Bok
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Abstract
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This study was to investigate the effects of Gyeonbi-Tang Treatment on the monosodium iodoacetate(MIA)-induced mild osteoarthritis in rats. Arthritis was induced by injection of MIA(0.25 mg) into knee joints of rats. Arthritic rats were divided into control(n=8) and treated(n=8) group. Control group was taken distilled water and treated group was taken extracts of Gyeonbi-Tang by orally for 20days. Body weights were measured at 0, 5, 10, 15, 20 days after MIA injection. At the end of experiment(20day after MIA injection), gross and histopathological examination on the articular structures of knee joints were performed. Proteoglycan(PG) contents in articular cartilages were analysed. And also, tumor necrosis factor-α(TNF-α) and interleukin-1β(IL-1β) contents in synovial fluids were measured by ELISA method. Body weights of the treated group were significantly increased compared with control group at 15, 20 days after injection. Grossly, the severity of osteoarthritis in the treated group were alleviated compared with control group. PG contents in articular cartilages of the treated group were increased compared with control group. Histopathologically, osteoarthritic scores of the treated group was decreased compared with the control group. TNF-α contents in synovial fluids of the treated group were significantly decreased compared with control group. On the basis of these results, we concluded that Gyeonbi-Tang Treatment has anti-arthritic effects on the monosodium iodoacetate-induced mild osteoarthritis in rats. And it’s effects were related with reduced secretion of TNF-α from synovial membranes.
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KEYWORD
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monosodium iodoacetate, osteoarthritis, Gyeonbi-Tang, TNF-α
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